T9652
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T9652
Sigma
Terfenadine
| Synonym: | α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| CAS Number: | 50679-08-8 |
| Linear Formula: | C32H41NO2 |
| Molecular Weight: | 471.67 |
| EC Number: | 256-710-8 |
| MDL number: | MFCD00079622 |
| PubChem Substance ID: | 24277779 |
Description
| Biochem/physiol Actions | Non-sedating second generation H1 histamine receptor antagonist. Mainly metabolized by Cyp3A4, 5, 7. Inhibits CYP2C8. |
Properties
| Gene Information | human ... ABCB1(5243), CYP2C8(1558), CYP3A4(1576), HRH1(3269), IL4(3565), IL5(3567), KCNH1(3756), KCNH2(3757) |
| rat ... Hrh1(24448) | |
| mouse ... Abcb1a(18671), Abcb1b(18669) | |
| storage temp. | 2-8°C |
Safety
| WGK Germany | 2 |
| RTECS | TM4969000 |
References
| reference | Taglialatela, et al., Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity. Clin. Exp. Allergy 29, 182, (1999) |
| Ohtani, et al., Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes. J. Pharm. Pharmacol. 51, 1059, (1999) Abstract | |
| Yun, C.H., et al. Drug Metab. Dispos. 21, 403-409, (1993) | |
| Ong, C.E., et al. Br. J. Clin. Pharmacol. 50, 573-580, (2000) |
